Edible mycorrhizal species Lactarius controversus Pers. 1800 as a source of antioxidant and cytotoxic agents
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Date
2016-03
Authors
Novaković, Aleksandra
Karaman, Maja A.
Milovanović, Ivan
Belović, Miona 
Rašeta, Milena M.
Radusin, Tanja
Ilić, Nebojša
Journal Title
Journal ISSN
Volume Title
Publisher
Savez hemijskih inženjera Srbije
Abstract
The aim of this work was to study chemical profile and antioxidant and cytotoxic activities of ethanol and water extracts of Lactarius controversus (Pers.) 1800 mushroom species growing in eastern Serbia. The chemical characterization of phenolic compounds performed by HPLC-MS/MS demonstrated the presence of quinic acid among others. Determination of antioxidant activity, including radical scavenging effects on DPPH•, NO•, OH• and SOA radicals and ferric reducing ability was investigated. The highest DPPH radical scavenging effect was obtained for water extract (LcAq) while ethanol extract (LcEtOH) demonstrated the highest FRAP activity. Hexane extract applied in antibacterial assay against three pathogenic strains demonstrated antibacterial effect only against S. aureus ATCC25922. Anti-proliferative properties against estrogen dependent MCF 7 breast cancer cell lines using MTT showed higher activity for ethanolic extract.
Description
peer-reviewed
Keywords
lactarius controversus, phenolic compounds, quinic acid, antioxidants, cytotoxic agents
Citation
Novaković, A.R., Karaman, M.A., Milovanović, I.Lj., Belović, M.M., Rašeta, M.J., Radusin, T.I., Ilić, N.M. (2016) Edible mycorrhizal species Lactarius controversus Pers. 1800 as a source of antioxidant and cytotoxic agents. Hemijska industrija,70, 113–122. DOI: 10.2298/HEMIND141229017N