Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract
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Date
2014-10-29
Authors
Ilić, Nebojša 
Dey, Moul
Poulev, Alexander A.
Logendra, Sithes
Kuhn, Peter E.
Raskin, Ilya
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
The ethanolic extract of grains of paradise (Aframomum melegueta Schum, Zingiberaceae) has been evaluated for inhibitory activity on cyclooxygenase-2 (COX-2) enzyme, in vivo for the anti-inflammatory activity and expression of several pro-inflammatory genes. Bioactivity-guided fractionation showed that the most active COX-2 inhibitory compound in the extract was [6]-paradol. [6]-Shogaol, another compound from the extract, was the most active inhibitory compound in pro-inflammatory gene expression assays. In a rat paw edema model, the whole extract reduced inflammation by 49% at 1000 mg/kg. Major gingerols from the extract [6]-paradol, [6]-gingerol, and [6]-shogaol reduced inflammation by 20, 25 and 38%. respectively when administered individually at a dose of 150 mg/kg. [6]-Shogaol efficacy was at the level of aspirin, used as a positive control. Grains of paradise extract has demonstrated an anti-inflammatory activity, which is in part due to the inhibition of COX-2 enzyme activity and expression of pro-inflammatory genes.
Description
peer-reviewed
Keywords
Aframomum melegueta Schum, anti-inflammatory, COX-2, gingerols, grains of paradise, paw edema, Zingiberaceae
Citation
N.M. Ilić, M. Dey, A. Poulev, S. Logendra, P. Kuhn, I. Raskin. Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract. Journal of Agricultural and Food Chemistry, 62, 43 (2014) 10452–10457. DOI: 10.1021/jf5026086