Antiproliferative properties of honey from Serbia, Kosovo and Bosnia and Herzegovina

Simple item page
dc.contributor.authorSakač, Marijana
dc.contributor.authorJovanov, Pavle
dc.contributor.authorMarić, Aleksandar
dc.contributor.authorČetojević-Simin, Dragana
dc.contributor.authorNovaković, Aleksandra
dc.contributor.authorPlavšić, Dragana
dc.contributor.authorŠkrobot, Dubravka
dc.date.accessioned2023-07-11T11:56:35Z
dc.date.available2023-07-11T11:56:35Z
dc.date.issued2022-06
dc.description.abstractHoney is a natural sweetener produced by honeybees using nectar. The type of honey is determined by the type of pollen, i.e. nectar, insect secretions, as well as climatic conditions and soil composition. The health benefits of honey, used for centuries for therapeutic purposes, derive from its antioxidant nature, antimicrobial and antiproliferative activity. With the aim to assess the antiproliferative activity of different types of honey characteristic for the region, nineteen samples (acacia, linden, heather, sunflower, phacelia, basil, anise, sage, chestnut, hawthorn, buckwheat, lavender and meadow) were collected from different locations in the Republic of Serbia, Kosovo and Bosnia and Herzegovina and examined. Honey samples were also tested for physicochemical parameters (moisture, pH value, electrical conductivity, free acidity and HMF) to ensure that they meet the requirements for honey quality. Based on the obtained results of honey physicochemical profile, it was concluded that all tested samples were in accordance with the regulations of national and EU regulations. The antiproliferative potential of honey samples was assessed by in vitro tests using tumor cell lines: HeLa (cervcal carcinoma), MCF7 (breast epithelial adenocarcinoma), HT-29 (colon adenocarcinoma) and MRC-5 (normal fetal lung fibroblasts). The highest antiproliferative activity was obtained by linden honey sample 1 (IC50 MCF7 = 7.46 ± 1.18 mg/mL and IC50 HeLa =12.4 ± 2.00 mg/mL) and meadow sample 2 (IC50 MCF7 = 12.0 ± 0.57 mg/mL, IC50 HeLa = 16.9 ± 1.54 mg/mL and IC50 HT-29 = 23.7 ± 1.33 mg/mL) towards breast (MCF7), cervix (HeLa) and colon (HT-29) cancer cells. Active components other than sugars contributed to cell growth activity. Probably, antiproliferative activity was achieved by polyphenols.en_US
dc.description.sponsorshipThis work was financially supported by the Ministry of Education, Science and Technological Development, Republic of Serbia (Contract No. 451-03-68/2022-14/200222).en_US
dc.identifier.citationSakač, M., Jovanov, P., Marić, A., Četojević-Simin, D., Novaković, A., Plavšić, D., Škrobot, D. (2022). Antiproliferative properties of honey from Serbia, Kosovo and Bosnia and Herzegovina. XI International Conference on Social and Technological Development – STED 2022, Trebinje, Bosnia and Herzegovina, p. 120.en_US
dc.identifier.issn2637-3298
dc.identifier.urihttp://oa.fins.uns.ac.rs/handle/123456789/163
dc.language.isoenen_US
dc.subjecthoneyen_US
dc.subjectantiproliferative activityen_US
dc.titleAntiproliferative properties of honey from Serbia, Kosovo and Bosnia and Herzegovinaen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dcterms.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200222/RS//

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Book-of-Abstracts_2022.pdf
Size:
508.47 KB
Format:
Adobe Portable Document Format
Description:
This file represents the Book of Abstracts of the XI International Conference on Social and Technological Development – STED 2022, Trebinje, Bosnia and Herzegovina.
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
22.51 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Conference paper