Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract

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dc.contributor.authorIlić, Nebojša
dc.contributor.authorDey, Moul
dc.contributor.authorPoulev, Alexander A.
dc.contributor.authorLogendra, Sithes
dc.contributor.authorKuhn, Peter E.
dc.contributor.authorRaskin, Ilya
dc.date.accessioned2017-04-26T15:07:28Z
dc.date.available2017-04-26T15:07:28Z
dc.date.issued2014-10-29
dc.descriptionpeer-revieweden_US
dc.description.abstractThe ethanolic extract of grains of paradise (Aframomum melegueta Schum, Zingiberaceae) has been evaluated for inhibitory activity on cyclooxygenase-2 (COX-2) enzyme, in vivo for the anti-inflammatory activity and expression of several pro-inflammatory genes. Bioactivity-guided fractionation showed that the most active COX-2 inhibitory compound in the extract was [6]-paradol. [6]-Shogaol, another compound from the extract, was the most active inhibitory compound in pro-inflammatory gene expression assays. In a rat paw edema model, the whole extract reduced inflammation by 49% at 1000 mg/kg. Major gingerols from the extract [6]-paradol, [6]-gingerol, and [6]-shogaol reduced inflammation by 20, 25 and 38%. respectively when administered individually at a dose of 150 mg/kg. [6]-Shogaol efficacy was at the level of aspirin, used as a positive control. Grains of paradise extract has demonstrated an anti-inflammatory activity, which is in part due to the inhibition of COX-2 enzyme activity and expression of pro-inflammatory genes.en_US
dc.description.sponsorshipResearch supported by Phytomedics Inc. (Jamesburg NJ, USA); NIH Center for Dietary Supplements Research on Botanicals and Metabolic Syndrome, Grant 1-P50 AT002776-01; Fogarty International Center of the NIH under U01TW006674 for the International Cooperative Biodiversity Groups; and Rutgers University. Additional support came from the National Center for Complementary and Alternative Medicine of NIH under 1-K99 AT004245-01.en_US
dc.identifier.citationN.M. Ilić, M. Dey, A. Poulev, S. Logendra, P. Kuhn, I. Raskin. Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract. Journal of Agricultural and Food Chemistry, 62, 43 (2014) 10452–10457. DOI: 10.1021/jf5026086en_US
dc.identifier.issn0021-8561
dc.identifier.urihttp://oa.fins.uns.ac.rs/handle/123456789/14
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofseries1;0010
dc.subjectAframomum melegueta Schumen_US
dc.subjectanti-inflammatoryen_US
dc.subjectCOX-2en_US
dc.subjectgingerolsen_US
dc.subjectgrains of paradiseen_US
dc.subjectpaw edemaen_US
dc.subjectZingiberaceaeen_US
dc.titleAnti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extracten_US
dc.title.alternative-en_US
dc.typeinfo:eu-repo/semantics/articleen_US
dcterms.rightsinfo:eu-repo/semantics/openAccess

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