Can Pumpkin Save us of Doxorubicin Induced Cardiotoxicity?

dc.contributor.authorBosanac, Milana
dc.contributor.authorAmidžić, Jelena
dc.contributor.authorStefanovic, Maja
dc.contributor.authorRadic, Jelena
dc.contributor.authorKolarov-Bjelobrk, Ivana
dc.contributor.authorJanicic, Stefan
dc.contributor.authorGojkovic, Zdenka
dc.contributor.authorLazić, Bojana
dc.contributor.authorĐokanović, Dejan
dc.contributor.authorMišan, Aleksandra
dc.contributor.authorCvetković, Biljana
dc.contributor.authorStupar, Alena
dc.contributor.authorMartic, Nikola
dc.contributor.authorAndrejic-Visnjic, Bojana
dc.date.accessioned2023-07-20T15:28:31Z
dc.date.available2023-07-20T15:28:31Z
dc.date.issued2023-02
dc.description.abstractDoxorubicin (DOX) is one of the drugs necessary for the treatment of the 10 most common types of cancer. The leading adverse effect limiting clinical use of DOX is cardiotoxicity. Given that literature data indicate a protective role of carotenoids in doxorubicin-induced toxicity, in our study we compared the cardioprotective effect of a mixture of pumpkin carotenoids and a commercially available antioxidant preparation. Animals were distributed in 8 groups (Control - S; NADES - N; Doxorubicin - Dox; Carotenoids - Car; CardiofortIN - CF; NADES-Doxorubicin - N-Dox; Carotenoids-Doxorubicin - Car-Dox; CardiofortIN-Doxorubicin - CF-Dox). Histological sections were stained with the hematoxylin-eosin (HE) and analyzed for the presence of myocardial damage by doxorubicin damage score (DDS). From the heart tissue homogenate were determined the intensity of lipid peroxidation and specific antioxidative enzyme activity (superoxide dismutase; catalase; glutathione S-transferase; glutathione peroxidase). In Car-DOX and CF-DOX groups, lipid peroxidation is significantly reduced compared to DOX group. Pretreatment of animals with carotenoids and in lesser extent with CardiofortIN led to higher antioxidative enzymes activity, compared to DOX group. Pretreated with carotenoids, only 50 % of animals had some degree of myocardial damage, and no animals had extensive damage. CardiofortIN pretreatment showed less protective effect. Pretreatment with carotenoid extract, reduced DDS significantly, so Car-DOX group has changes equivalent to mild myocardial damage. Although CardiofortIN pretreatment lowered DDS score values, animals still had moderate level of myocardium damage. This in vivo study and its findings indicate that carotenoids extracted from pumpkin may be a promising cardioprotective agent against doxorubicin induced cardiotoxicity, at least in part mediated through inhibition of DOX-induced oxidative stress.en_US
dc.description.sponsorshipThis research is financially supported by the Autonomous Province of Vojvodina (Project No 142-451-2543/2021-02)en_US
dc.identifier.citationBosanac, M., Amidzic, J., Stefanovic, M., Radic, J., Kolarov-Bjelobrk, I., Janicic, S., ... & Andrejic-Visnjic, B. (2023). ¿ Puede la Calabaza Salvarnos de la Cardiotoxicidad Inducida por Doxorrubicina?. International Journal of Morphology, 41(1), 231-236.en_US
dc.identifier.issn0717-9367
dc.identifier.scopus2-s2.0-85153597297
dc.identifier.urihttp://oa.fins.uns.ac.rs/handle/123456789/331
dc.language.isoen_USen_US
dc.publisherSociedad Chilena de Anatomiaen_US
dc.rightsOpenAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiotoxicityen_US
dc.subjectDoxorubicinen_US
dc.subjectCarotenoidsen_US
dc.subjectCardiofortINen_US
dc.titleCan Pumpkin Save us of Doxorubicin Induced Cardiotoxicity?en_US
dc.title.alternativePuede la Calabaza Salvarnos de la Cardiotoxicidad Inducida por Doxorrubicina?en_US
dc.typeinfo:eu-repo/semantics/articleen_US

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