Calcium-dependent antibacterial activity of donkey’s milk against Salmonella

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dc.contributor.authorŠarić, Ljubiša
dc.contributor.authorPezo, Lato
dc.contributor.authorŠarić, Bojana
dc.contributor.authorPlavšić, Dragana
dc.contributor.authorJovanov, Pavle
dc.contributor.authorKarabasil, Neđeljko
dc.contributor.authorGubić, Jasmina
dc.date.accessioned2018-07-10T14:23:19Z
dc.date.available2018-07-10T14:23:19Z
dc.date.issued2017-02
dc.descriptionpeer-revieweden_US
dc.description.abstractThe aim of this study was to examine the antibacterial activity of raw donkey’s milk (DM) against Salmonella Enteritidis and Salmonella Typhimurium as well as to determine the dependence of this antibacterial activity on calcium, lysozyme and lactoferrin content. Antibacterial assays were conducted in DM artificially contaminated with these Salmonellaserotypes and then incubated at 38 °C for 8 hours. Calcium concentration was found to have a strong influence on the antibacterial activity of the contaminated DM samples supplemented with CaCl2 and EDTA. The antibacterial activity of DM against the tested Salmonella strains was observed to be strongly calcium dependent, with the addition of CaCl2 to DM samples improving its antibacterial potential against both pathogens. Salmonella Enteritidis appeared to be less sensitive to the antimicrobial agents in DM than S. Typhimurium. One explanation is the calcium-dependant antibacterial activity of DM is attributable to the calcium-binding ability of its lysozyme. Lysozyme may be the main antibacterial agent, most probably via a nonenzymatic mode of action against tested Salmonella strains.en_US
dc.description.sponsorshipThis work is a part of the National Project (TR–31029) financially supported by the Ministry of Education and Science, Republic of Serbia. The authors are grateful to Slobodan Simić and Nikola Nilić (Special Nature Reserve “Zasavica”, Serbia) for providing the milk samples.en_US
dc.identifier.citationLj. Šarić, L. Pezo, B. Šarić, D. Plavšić, P. Jovanov, N. Karabasil, J. Gubić. Calcium-dependent antibacterial activity of donkey’s milk against Salmonella. Annals of Microbiology, 67 (2017) 185-194. DOI: 10.1007/s13213-016-1250-2en_US
dc.identifier.issn1590-4261
dc.identifier.urihttp://oa.fins.uns.ac.rs/handle/123456789/105
dc.language.isoenen_US
dc.publisherSpringer Berlin Heidelbergen_US
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31029/RS/
dc.relation.ispartofseries001;0100
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDonkey’s milken_US
dc.subjectantibacterial activityen_US
dc.subjectSalmonellaen_US
dc.subjectcalciumen_US
dc.titleCalcium-dependent antibacterial activity of donkey’s milk against Salmonellaen_US
dc.title.alternative-en_US
dc.typeinfo:eu-repo/semantics/articleen_US

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