The Application of Ultrasonic Waves and Microwaves to Improve Antihyperglycaemic and Antimicrobial Activities of Marrubium vulgare Extracts

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dc.contributor.authorGavarić, Aleksandra
dc.contributor.authorVladić, Jelena
dc.contributor.authorVujetić, Jelena
dc.contributor.authorRadnović, Dragan
dc.contributor.authorVolarić, Ana
dc.contributor.authorŽivković, Jelena
dc.contributor.authorŠavikin, Katarina
dc.contributor.authorVidović, Senka
dc.date.accessioned2023-07-17T07:30:31Z
dc.date.available2023-07-17T07:30:31Z
dc.date.issued2022-10-25
dc.description.abstractHaving scarce information about ultrasound assisted extraction (UAE) and microwave assisted extraction (MAE) of white horehound (Marrubium vulgare L.), the idea has emerged to determine the optimal process parameters for the maximization of polyphenols and to compare the efficiency of these green extraction technologies. The optimal UAE parameters are temperature of 73.6 ◦C, extraction time of 40 min and ultrasound power of 30.3 W/L, while the optimal MAE parameters are 63.8% ethanol, extraction time of 15 min and microwave power of 422 W. Extract obtained at optimal UAE parameters shows the highest antihyperglycemic activity (α-amylase inhibition: 50.63% and α-glucosidase inhibition: 48.67%), which can potentially be explained by the presence of chlorogenic acid and quercetin, which were not identified in the macerates. The most sensitive bacterial strain to optimal ultrasonic extract is Bacillus cereus, whereas the most sensitive fungal strain is Saccharomyces cerevisiae.en_US
dc.description.sponsorshipThis research was funded by the Program of Ministry of Education, Science and Technolog ical Development of Republic of Serbia; Projects No. 451-03-68/2022-14/200134 and No. 451-03-68/ 2022-14/200125.en_US
dc.identifier.doi10.3390/antibiotics11111475
dc.identifier.issn2079-6382
dc.identifier.scopus2-s2.0-85141814447
dc.identifier.urihttp://oa.fins.uns.ac.rs/handle/123456789/290
dc.identifier.wos000883353400001
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200222/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200134/RS//
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMarrubium vulgareen_US
dc.subjectultrasound extractionen_US
dc.subjectmicrowave extractionen_US
dc.subjectantihyperglycaemic activityen_US
dc.subjectantimicrobial activityen_US
dc.titleThe Application of Ultrasonic Waves and Microwaves to Improve Antihyperglycaemic and Antimicrobial Activities of Marrubium vulgare Extractsen_US
dc.typeArticleen_US
dc.typeinfo:eu-repo/semantics/article

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