Role of Arthrospira Platensis in Preventing and Treating High-Fat Diet-Induced Hypercholesterolemia in Adult Rats

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dc.contributor.authorCacciola, Nunzio Antonio
dc.contributor.authorDe Cicco, Paola
dc.contributor.authorMilanović, Maja
dc.contributor.authorMilovanović, Ivan
dc.contributor.authorMišan, Aleksandra
dc.contributor.authorKojić, Danijela
dc.contributor.authorSimeunović, Jelica
dc.contributor.authorBlagojević, Dajana
dc.contributor.authorPopović, Tamara
dc.contributor.authorArsić, Aleksandra
dc.contributor.authorPilija, Vladimir
dc.contributor.authorMandić, Anamarija
dc.contributor.authorBorrelli, Francesca
dc.contributor.authorMilić, Nataša
dc.date.accessioned2024-12-12T10:01:33Z
dc.date.available2024-12-12T10:01:33Z
dc.date.issued2024-06-11
dc.description.abstractHyperlipidaemia is a recognised risk factor for cardiovascular disease. In this study, the antihyperlipidaemic properties of spirulina (Arthrospira platensis, strain S2 from Serbia) were tested in adult Wistar rats before and after induction of hypercholesterolaemia by a high-fat diet (HFD) to compare the preventive with the curative effect. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), alanine transaminase (ALT) and aspartate transaminase (AST) levels were measured in the blood samples. The chemical composition (lipids, proteins and cholesterol) and the content of bile acids in the faeces of the animals were also analysed. Feeding rats with an atherogenic diet for 10 weeks led to the successful development of hyperlipidaemia, as serum TC and LDL-C levels as well as lipids, cholesterol and bile acids in the animals’ faeces were significantly increased. Pre- and post-treatment with spirulina led to a reduction in serum LDL, TC and ALT levels. Administration of spirulina resulted in both a significant increase in primary bile acids excretion and a decrease in bile acids metabolism, with pre-treatment being more effective than post-treatment in some cases. These results suggest that increased excretion of bile acids as well as an effect on the gut microbiota may be the mechanism responsible for the anti-hyperlipidaemic activity of the tested spirulina strain.
dc.description.sponsorshipThis research was funded by: Provincial Secretariat for Higher Education and Scientific Research, AP Vojvodina, Republic of Serbia [Grant number 142-451-3509/2023-01] and Ministry of Science, Technological Development and Innovation of Republic of Serbia, GA 451-03-66/2024-03/200222.
dc.identifier.citationCacciola, N.A.; De Cicco, P.; Milanović, M.; Milovanović, I.; Mišan, A.; Kojić, D.; Simeunović, J.; Blagojević, D.; Popović, T.; Arsić, A.; et al. Role of Arthrospira Platensis in Preventing and Treating High-Fat Diet-Induced Hypercholesterolemia in Adult Rats. Nutrients 2024, 16, 1827.
dc.identifier.doi10.3390/nu16121827
dc.identifier.issn2072-6643
dc.identifier.scopus2-s2.0-85197136737
dc.identifier.urihttps://oa.fins.uns.ac.rs/handle/123456789/415
dc.identifier.wos001256787100001
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofseries16; 1827
dc.subjectspirulina
dc.subjecthyperlipidaemia
dc.subjectbile acids
dc.subjecthepatoprotective effects
dc.subjectlipid parameters
dc.titleRole of Arthrospira Platensis in Preventing and Treating High-Fat Diet-Induced Hypercholesterolemia in Adult Rats
dc.typeArticle

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