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Can Pumpkin Save us of Doxorubicin Induced Cardiotoxicity?

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dc.contributor.author Bosanac, Milana
dc.contributor.author Amidžić, Jelena
dc.contributor.author Stefanovic, Maja
dc.contributor.author Radic, Jelena
dc.contributor.author Kolarov-Bjelobrk, Ivana
dc.contributor.author Janicic, Stefan
dc.contributor.author Gojkovic, Zdenka
dc.contributor.author Lazić, Bojana
dc.contributor.author Đokanović, Dejan
dc.contributor.author Mišan, Aleksandra
dc.contributor.author Cvetković, Biljana
dc.contributor.author Stupar, Alena
dc.contributor.author Martic, Nikola
dc.contributor.author Andrejic-Visnjic, Bojana
dc.date.accessioned 2023-07-20T15:28:31Z
dc.date.available 2023-07-20T15:28:31Z
dc.date.issued 2023-02
dc.identifier.citation Bosanac, M., Amidzic, J., Stefanovic, M., Radic, J., Kolarov-Bjelobrk, I., Janicic, S., ... & Andrejic-Visnjic, B. (2023). ¿ Puede la Calabaza Salvarnos de la Cardiotoxicidad Inducida por Doxorrubicina?. International Journal of Morphology, 41(1), 231-236. en_US
dc.identifier.issn 0717-9367
dc.identifier.uri http://oa.fins.uns.ac.rs/handle/123456789/331
dc.description.abstract Doxorubicin (DOX) is one of the drugs necessary for the treatment of the 10 most common types of cancer. The leading adverse effect limiting clinical use of DOX is cardiotoxicity. Given that literature data indicate a protective role of carotenoids in doxorubicin-induced toxicity, in our study we compared the cardioprotective effect of a mixture of pumpkin carotenoids and a commercially available antioxidant preparation. Animals were distributed in 8 groups (Control - S; NADES - N; Doxorubicin - Dox; Carotenoids - Car; CardiofortIN - CF; NADES-Doxorubicin - N-Dox; Carotenoids-Doxorubicin - Car-Dox; CardiofortIN-Doxorubicin - CF-Dox). Histological sections were stained with the hematoxylin-eosin (HE) and analyzed for the presence of myocardial damage by doxorubicin damage score (DDS). From the heart tissue homogenate were determined the intensity of lipid peroxidation and specific antioxidative enzyme activity (superoxide dismutase; catalase; glutathione S-transferase; glutathione peroxidase). In Car-DOX and CF-DOX groups, lipid peroxidation is significantly reduced compared to DOX group. Pretreatment of animals with carotenoids and in lesser extent with CardiofortIN led to higher antioxidative enzymes activity, compared to DOX group. Pretreated with carotenoids, only 50 % of animals had some degree of myocardial damage, and no animals had extensive damage. CardiofortIN pretreatment showed less protective effect. Pretreatment with carotenoid extract, reduced DDS significantly, so Car-DOX group has changes equivalent to mild myocardial damage. Although CardiofortIN pretreatment lowered DDS score values, animals still had moderate level of myocardium damage. This in vivo study and its findings indicate that carotenoids extracted from pumpkin may be a promising cardioprotective agent against doxorubicin induced cardiotoxicity, at least in part mediated through inhibition of DOX-induced oxidative stress. en_US
dc.description.sponsorship This research is financially supported by the Autonomous Province of Vojvodina (Project No 142-451-2543/2021-02) en_US
dc.language.iso en_US en_US
dc.publisher Sociedad Chilena de Anatomia en_US
dc.rights OpenAccess
dc.rights info:eu-repo/semantics/openAccess
dc.subject Cardiotoxicity en_US
dc.subject Doxorubicin en_US
dc.subject Carotenoids en_US
dc.subject CardiofortIN en_US
dc.title Can Pumpkin Save us of Doxorubicin Induced Cardiotoxicity? en_US
dc.title.alternative Puede la Calabaza Salvarnos de la Cardiotoxicidad Inducida por Doxorrubicina? en_US
dc.type info:eu-repo/semantics/article en_US
dc.identifier.scopus 2-s2.0-85153597297


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