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Biological activities and chemical composition of Morus leaves extracts obtained by maceration and supercritical fluid extraction

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dc.contributor.author Radojković Marija
dc.contributor.author Zeković Zoran
dc.contributor.author Mašković Pavle
dc.contributor.author Vidović, Senka
dc.contributor.author Mandić, Anamarija
dc.contributor.author Mišan, Aleksandra
dc.contributor.author Đurović Saša
dc.date info:eu-repo/date/embargoEnd/2017-11-21
dc.date.accessioned 2017-11-21T16:33:14Z
dc.date.available 2017-11-21T16:33:14Z
dc.date.issued 2016-11
dc.identifier.citation M. Radojković, Z. Zeković, P. Mašković, S. Vidović, A. Mandić, A. Mišan, S. Đurović. Biological activities and chemical composition of Morus leaves extracts obtained by maceration and supercritical fluid extraction. Journal of Supercritical Fluids, 117 (2016), 50–58. DOI: 10.1016/j.supflu.2016.05.004 en_US
dc.identifier.issn 0896-8446
dc.identifier.uri http://oa.fins.uns.ac.rs/handle/123456789/29
dc.description peer-reviewed en_US
dc.description.abstract Supercritical CO2 extraction of Morus species (Morus alba and Morus nigra) was performed and compared with maceration as conventional extraction technique. Composition and biological activity of extracts were evaluated. The thirteen fatty acids were quantified in obtained extracts by GC-FID analysis. Their percentages varying from 0.33% for palmitoleic acid (C16:1) to 37.57% for α-linolenic acid (C18:3 n3). The main fatty acids were palmitic acid (C16:0) (26.38 and 25.99%), α-linolenic acid (C18:3 n3) (34.97 and 37.57%) and linoleic acid (C18:2 n6c) (14.76 and 16.05%). Total phenolic and flavonoid contents were determined using spectrophotometric methods, while phenolic profile was determined using HPLC-DAD analysis. Antioxidant and cytotoxic activities were also determined. Main phenolic compound was caffeic acid. Rutin, derivatives of caffeic acid and quercetin were also presented in high amounts. Our findings demonstrated that Morus CO2 extracts possess significant characteristics and may be suggested as a new potential source of natural compounds. en_US
dc.description.sponsorship Financial support of this work by the Serbian Ministry of Education, Science and Technological Development Project No. TR 31013 is gratefully acknowledged. We are grateful to Dr Goran Anačkov, Faculty of Natural Sciences, University of Novi Sad, Serbia, for support in term of confirmed and deposited Morus nigra L. and Morus alba L. at the BUNS Herbarium. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31013/RS//
dc.relation.ispartofseries 001;0024
dc.rights info:eu-repo/semantics/embargoedAccess
dc.subject morus en_US
dc.subject supercritical CO2 extraction en_US
dc.subject fatty acids en_US
dc.subject phenolic profile en_US
dc.subject antioxidant activity en_US
dc.subject cytotoxic activity en_US
dc.title Biological activities and chemical composition of Morus leaves extracts obtained by maceration and supercritical fluid extraction en_US
dc.title.alternative - en_US
dc.type info:eu-repo/semantics/article en_US


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