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Synthesis and Characterization of Chitosan-Acrylic Acid Based Hydrogels and Investigation the Properties of Bilayered Design with Incorporated Alginate Beads

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dc.contributor.author Erceg, Tamara
dc.contributor.author Brakus, Gaja
dc.contributor.author Stupar, Alena
dc.contributor.author Cvetinov, Miroslav
dc.contributor.author Hadnađev, Miroslav
dc.contributor.author Ristić, Ivan
dc.date.accessioned 2023-07-13T13:19:56Z
dc.date.available 2023-07-13T13:19:56Z
dc.date.issued 2022-05-16
dc.identifier.citation Erceg, T., Brakus, G., Stupar, A., Cvetinov, M., Hadnađev, M., & Ristić, I. (2022). Synthesis and Characterization of Chitosan-Acrylic Acid Based Hydrogels and Investigation the Properties of Bilayered Design With Incorporated Alginate Beads. Journal of Polymers and the Environment, 30, 3737–3760. en_US
dc.identifier.issn 1572-8919
dc.identifier.uri http://oa.fins.uns.ac.rs/handle/123456789/229
dc.description.abstract The paper presents the synthesis of hydrogels via free-radical polymerization, based on Chitosan (CS) grafted with Acrylic acid (AA), using a two-step procedure. Free-radical polymerization has given strong hydrogels with compact structure, dominant elastic behavior, and long linear viscoelastic region. The results of rheological studies have shown that obtained hydrogels have significantly improved mechanical properties in comparison to chitosan hydrogels obtained by other sustainable methods. A step forward in the investigation of the potential application of chitosan hydrogels in wound dressing systems has been made by preparation of the bilayer design by embedding a layer of active compound-loaded alginate beads into the contact surface between two conjoined units of CS/AA hydrogels. Wild garlic (Allium ursinum L.) dried extract was used as an active compound because of its antimicrobial activity and green properties. This system has demonstrated pH-dependent release of extract and higher shear elastic modulus values than ordinary disc gels. A conducted study has given preliminary results for the possible application of bilayer chitosan-based hydrogels in wound dressing systems and represents the first step towards extrapolating the proposed design across other application fields. en_US
dc.description.sponsorship This study was supported by Ministry of Education, Science and Technological Development, Republic of Serbia, project number 451-03-68/2020-14/ 200134 for financial support. en_US
dc.language.iso en en_US
dc.publisher Springer Nature en_US
dc.relation info:eu-repo/grantAgreement/MESTD/inst-2020/200134/RS//
dc.rights embargoedAccess
dc.subject Chitosan hydrogels en_US
dc.subject Free-radical polymerization en_US
dc.subject Alginate beads en_US
dc.subject Bilayer design en_US
dc.subject Rheological properties en_US
dc.title Synthesis and Characterization of Chitosan-Acrylic Acid Based Hydrogels and Investigation the Properties of Bilayered Design with Incorporated Alginate Beads en_US
dc.type info:eu-repo/semantics/article
dc.identifier.scopus 2-s2.0-85130199790
dc.identifier.wos 000796325000002
dc.identifier.doi 10.1007/s10924-022-02473-7


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