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Bioaccessibility and uptake by Caco-2 cells of carotenoids from cereal-based products enriched with butternut squash (Cucurbita moschata L.)

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dc.contributor.author Rošul, Milana
dc.contributor.author Đerić, Nataša
dc.contributor.author Mišan, Aleksandra
dc.contributor.author Pojić, Milica
dc.contributor.author Šimurina, Olivera
dc.contributor.author Halimi, Charlotte
dc.contributor.author Nowicki, Marion
dc.contributor.author Cvetković, Biljana
dc.contributor.author Mandić, Anamarija
dc.contributor.author Reboul, Emmanuelle
dc.date.accessioned 2023-07-11T13:13:10Z
dc.date.available 2023-07-11T13:13:10Z
dc.date.issued 2022-08-15
dc.identifier.citation Rošul, M., Đerić, N., Mišan, A., Pojić, M., Šimurina, O., Halimi, C., ... & Reboul, E. (2022). Bioaccessibility and uptake by Caco-2 cells of carotenoids from cereal-based products enriched with butternut squash (Cucurbita moschata L.). Food Chemistry, 385, 132595. en_US
dc.identifier.issn 0308-8146
dc.identifier.uri http://oa.fins.uns.ac.rs/handle/123456789/168
dc.description.abstract Enriching cereals-based products with bioactive compounds is a valuable strategy to improve product quality. We studied carotenoid bioaccessibility and intestinal uptake from a pumpkin-enriched porridge, cookies and sponge cakes by using in vitro digestion coupled with Caco-2 cell uptake. Among the carotenoids recovered in different products, α-carotene was the most important abundant one. However, lutein displayed a significantly higher bioaccessibility compared to α-carotene and β-carotene in baked products (up to 10.28% compared to 1.22% and 0.88%, respectively). α-Carotene was the only carotenoid recovered in Caco-2 cells after micelle incubation. Cookie micelles led to the highest percentage of α-carotene cell uptake (2.33% and 1.38% for cookies with butter and cookies with vegetable oil, respectively) compared to the other baked products, followed by dry pumpkin puree micelles (1.31%). Overall, our data show that both bioaccessiblity and cell uptake of carotenoids from cereal-based products are variable and highly depend on food formulation and structure. en_US
dc.description.sponsorship This research was funded by: -The Ministry of Education, Science and Technological Development of the Republic of Serbia (Contract No: 451-03-9/2022-14/200222), The Science Fund of the Republic of Serbia, PROMIS, Grant No. 6060592, DEStiny; -The French Ministry of higher education, research and innovation (Exchange program Hubert Curien Pavle Savić 2018-2019), -COST Action “European network to advance carotenoid research and applications in agro-food and health” EUROCAROTEN, CA15136, www.eurocaroten.eu, http://www.cost.eu/COST_Actions/ca/CA15136) supported by COST. en_US
dc.language.iso en en_US
dc.publisher ELSEVIER en_US
dc.rights embargoedAccess
dc.rights info:eu-repo/semantics/embargoedAccess
dc.subject In vitro Digestion en_US
dc.subject Micelles en_US
dc.subject Enterocytes en_US
dc.subject Bioavailability en_US
dc.subject Pumpkin en_US
dc.title Bioaccessibility and uptake by Caco-2 cells of carotenoids from cereal-based products enriched with butternut squash (Cucurbita moschata L.) en_US
dc.type info:eu-repo/semantics/article en_US
dcterms.relation info:eu-repo/grantAgreement/ScienceFundRS/Promis/6060592/RS//
dc.identifier.scopus 2-s2.0-85126789018
dc.identifier.wos 000794033800005
dc.identifier.doi 10.1016/j.foodchem.2022.132595


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