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Antioxidant and antiproliferative potential of fruiting bodies of the wild-growing king bolete mushroom, Boletus edulis (Agaricomycetes), from Western Serbia

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dc.contributor.author Novaković, Aleksandra
dc.contributor.author Karaman, Maja
dc.contributor.author Kaišarević, Sonja
dc.contributor.author Radusin, Tanja
dc.contributor.author Ilić, Nebojša
dc.date.accessioned 2018-07-10T14:40:57Z
dc.date.available 2018-07-10T14:40:57Z
dc.date.issued 2017-01
dc.identifier.citation Novakovic, A., Karaman, M., Kaisarevic, S., Radusin, T., Ilić, N. (2017) Antioxidant and antiproliferative potential of fruiting bodies of the wild-growing king bolete mushroom, Boletus edulis (Agaricomycetes), from Western Serbia. International Journal of Medicinal Mushrooms, 19, 1, 27–34. DOI: 10.1615/IntJMedMushrooms.v19.i1.30 en_US
dc.identifier.issn 1521-9437
dc.identifier.uri http://oa.fins.uns.ac.rs/handle/123456789/106
dc.description peer-reviewed en_US
dc.description.abstract The aim of this work was to study the bioactivity of crude aqueous and ethanolic extracts of Boletus edulis prepared from caps and stipes of wild-growing basidiocarps collected from the Prijepolje region (western Serbia). The bioactivity screening included antioxidant (2,2-diphenyl-l-picrylhydrazyl [DPPH], nitric oxide, super-oxide anion*, and hydroxyl radicals and ferric-reducing antioxidant power) and antiproliferative MTT assays (human breast MCF-7 cancer cell line). In addition, all extracts were primarily characterized by ultraviolet/visible spectrophotometry to determine total phenolic and flavonoid contents. The highest anti-DPPH and anti-hydroxyl radical activity were observed in aqueous B. edulis extract from the caps (half maximal inhibitory concentration [IC50] = 50.97 μg/ mL and 2.05 μg/mL, respectively), whereas the highest anti-nitric oxide radical activity was observed in aqueous B. edulis extract from the stipes (IC50 = 10.74 μg/mL). The ethanolic extract obtained from the mushroom stipe showed higher anti-superoxide anion radical activity (IC50 = 9.84 μg/mL) and ferric-reducing antioxidant power (22.14 mg ascorbic acid equivalents/g dry weight) compared with aqueous extracts. Total phenolic content for all extracts was similar but total flavonoid content was significantly higher in the aqueous B. edulis extract from the caps (4.5 mg quercetin equivalents/g dry weight). All crude extracts showed activity against the MCF-7 cell line, with the ethanolic extract of B. edulis prepared from stipes (IC50 = 56 μg/mL) being the most potent. This is, to our knowledge, the first report of the antiproliferative effects of crude aqueous and ethanolic extracts prepared from caps and stipes of wild-growing basidiocarps of B. edulis on the human breast MCF-7 cancer cell line. en_US
dc.description.sponsorship This study was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (projects III 46001 and OI 172058) en_US
dc.language.iso en en_US
dc.publisher Begell House en_US
dc.relation info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.relation info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172058/RS//
dc.relation.ispartofseries 001;0101
dc.rights info:eu-repo/semantics/openAccess
dc.subject antiradical and antiproliferative activity en_US
dc.subject Boletus edulis en_US
dc.subject fruiting body en_US
dc.subject medicinal and edible mush-rooms en_US
dc.subject phenolic compounds en_US
dc.title Antioxidant and antiproliferative potential of fruiting bodies of the wild-growing king bolete mushroom, Boletus edulis (Agaricomycetes), from Western Serbia en_US
dc.title.alternative - en_US
dc.type info:eu-repo/semantics/article en_US


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