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Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract

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dc.contributor.author Ilić, Nebojša
dc.contributor.author Dey, Moul
dc.contributor.author Poulev, Alexander A.
dc.contributor.author Logendra, Sithes
dc.contributor.author Kuhn, Peter E.
dc.contributor.author Raskin, Ilya
dc.date.accessioned 2017-04-26T15:07:28Z
dc.date.available 2017-04-26T15:07:28Z
dc.date.issued 2014-10-29
dc.identifier.citation N.M. Ilić, M. Dey, A. Poulev, S. Logendra, P. Kuhn, I. Raskin. Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract. Journal of Agricultural and Food Chemistry, 62, 43 (2014) 10452–10457. DOI: 10.1021/jf5026086 en_US
dc.identifier.issn 0021-8561
dc.identifier.uri http://oa.fins.uns.ac.rs/handle/123456789/14
dc.description peer-reviewed en_US
dc.description.abstract The ethanolic extract of grains of paradise (Aframomum melegueta Schum, Zingiberaceae) has been evaluated for inhibitory activity on cyclooxygenase-2 (COX-2) enzyme, in vivo for the anti-inflammatory activity and expression of several pro-inflammatory genes. Bioactivity-guided fractionation showed that the most active COX-2 inhibitory compound in the extract was [6]-paradol. [6]-Shogaol, another compound from the extract, was the most active inhibitory compound in pro-inflammatory gene expression assays. In a rat paw edema model, the whole extract reduced inflammation by 49% at 1000 mg/kg. Major gingerols from the extract [6]-paradol, [6]-gingerol, and [6]-shogaol reduced inflammation by 20, 25 and 38%. respectively when administered individually at a dose of 150 mg/kg. [6]-Shogaol efficacy was at the level of aspirin, used as a positive control. Grains of paradise extract has demonstrated an anti-inflammatory activity, which is in part due to the inhibition of COX-2 enzyme activity and expression of pro-inflammatory genes. en_US
dc.description.sponsorship Research supported by Phytomedics Inc. (Jamesburg NJ, USA); NIH Center for Dietary Supplements Research on Botanicals and Metabolic Syndrome, Grant 1-P50 AT002776-01; Fogarty International Center of the NIH under U01TW006674 for the International Cooperative Biodiversity Groups; and Rutgers University. Additional support came from the National Center for Complementary and Alternative Medicine of NIH under 1-K99 AT004245-01. en_US
dc.language.iso en en_US
dc.publisher American Chemical Society en_US
dc.relation.ispartofseries 1;0010
dc.subject Aframomum melegueta Schum en_US
dc.subject anti-inflammatory en_US
dc.subject COX-2 en_US
dc.subject gingerols en_US
dc.subject grains of paradise en_US
dc.subject paw edema en_US
dc.subject Zingiberaceae en_US
dc.title Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract en_US
dc.title.alternative - en_US
dc.type Article en_US
dcterms.rights info:eu-repo/semantics/openAccess


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